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Chapter 20 - Peripheral Nerve and Neuromuscular Disorders
from Section 3 - Specific Neurological Disorders in Emergency Medicine
- By George A. Small, Sandeep Rana, Mara Aloi
Edited by Thomas P. Campbell, Allegheny Health Network, Pittsburgh, Kevin M. Kelly, Allegheny Health Network, Pittsburgh
Book:

Handbook of Emergency Neurology

Published online:

10 January 2024

Print publication:

17 August 2023, pp 295-306
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Summary

Guillain Barré syndrome (GBS) is an acquired neuromuscular disorder that presents as rapidly progressive weakness and numbness, usually in an ascending fashion. The underlying pathophysiology is monophasic inflammatory immune-mediated demyelinating polyneuropathy that in many cases is triggered by viral illnesses, usually a few weeks prior to the onset of syndrome. The majority of cases are in young adults, although it can occur in pediatric and elderly age groups. GBS should be considered in the differential diagnosis of new-onset rapidly progressing weakness in an otherwise healthy individual.