Laboratory and field studies were conducted to examine the influence of R-33865 (O, O-diethyl-O-phenol phosphorothioate) on the degradation rate of EPTC (S-ethyl dipropylthiocarbamate) in three soils that had a history of repeated EPTC application and exhibited accelerated degradation of EPTC. In field studies, addition of R-33865 to EPTC extended EPTC persistence in soil and provided increased shattercane [Sorghum bicolor (L.) Moench] control. In two soils that exhibited rapid EPTC degradation, addition of R-33865 to EPTC extended the half-life of EPTC from 9 to 18 days and from 6 to 15 days, respectively. Evolution of 14CO2 from 14C-carbonyl EPTC-treated soils with a prior history of EPTC treatment was significantly reduced when R-33865 was added; however, the initial lag period of EPTC degradation was not restored. Addition of R-33865 to EPTC on soils with no prior EPTC treatment did not extend persistence of EPTC in soil.