Fruits rich in phytochemicals have been shown to improve memory by protecting or enhancing neuronal functions mediated by neurotrophic factors, such as nerve growth factor (NGF), in the hippocampus. Mori Fructus (Morus alba L., Moraceae), also called mulberry, is used as a food, dietary supplement and an anti-ageing agent in traditional Oriental medicine. It is also known to contain abundant flavonoid compounds and to exhibit various pharmacological effects. The present study was performed to evaluate the memory-enhancing effect of Mori Fructus extract (ME) in mice, with a focus on NGF regulation. ME (20, 100 and 500 mg/kg per d for 7 d, per os) dose-dependently promoted NGF release in the mouse hippocampus, leading to phosphorylation of extracellular signal-regulated kinases and cyclic AMP response element-binding protein. ME significantly increased pre- and post-synapse formation, acetylcholine synthesisation, neuronal cell differentiation, neurite outgrowth and neuronal cell proliferation in the mouse hippocampus. Furthermore, ME significantly increased latency time in the passive avoidance task (P< 0·001) and recognition time of novel objects in the object recognition test (P< 0·05), indicating improvements in learning and memory. Taken together, these data suggest that ME exhibits a memory-enhancing effect via up-regulation of NGF.

Background: Memory enhancement programs that can significantly improve actual memory performance and subjective perceptions of everyday memory in elderly people are rare. This study was designed to evaluate a new memory enhancement program incorporating principles of successful aging, designed to enhance subjective and objective everyday memory in community-dwelling old people.

Methods: Two matched groups of 20 healthy community-dwelling elderly adults were assessed on measures of objective and subjective memory performance before and after participating in a memory enhancement or active control condition.

Results: Planned multivariate analysis of variance (MANOVA) on change scores showed that participants in the memory enhancement program improved significantly on both objective and subjective measures. Specifically, greater improvement was demonstrated on a verbal paired associates task, story recall, face recognition, contentment with memory, and use of memory strategies.

Conclusions: Although a fully randomized design was not used, the results are promising, suggesting that memory training incorporating principles of successful aging can enhance memory performance in healthy old people, objectively and subjectively.

Background: There are no existing epidemiological data on use of medications to enhance memory.

Method: A community survey was carried out in Canberra and Queanbeyan, Australia, of an electoral roll sample of 2551 adults aged 60–64 years. Data collected included self-reports of using medications to enhance memory, tests of memory and other cognitive functions, anxiety, depression, physical health and use of other medications.

Results: 2.8% of the sample reported using medications to enhance memory, the main ones being gingko biloba, vitamin E, bacopa (brahmi), and folic acid/B vitamins. Users were more likely to be female, to have subjective memory problems and to use other psychotropic medications. However, they did not differ in memory performance, anxiety, depression or physical health.

Discussion: Some older people are using complementary medications to improve their memory or prevent memory loss, despite the lack of strong evidence for their effectiveness. These people show no objective evidence of memory impairment