How individuals try to solve problems, from simple to life-threatening ones, has been a central question across the scientific landscape. Not surprisingly, disciplines have offered theories representing their unique perspectives from cost, psychological predispositions, social status, culture, power, and even genetic inheritance. What was common across these explanations, even as larger structures or context were considered to limit or enhance action, was the focus on individuals, the primary assumption of action as decision-making or help-seeking, and an internal cost-benefit mechanism. While providing many insights, this understanding of the basis of human action falls short. The social network perspective suggests a shift to the influence of others on social action and a reconsideration of underlying assumptions. This reflection considers how applying an approach where social networks are the engine of action produced the Social Organization Strategy framework, the Network Episode Model, subsequent revisions, and the multi-level, multi-disciplinary Network Embedded Symbiome. This chapter describes how this social network perspective guides a new research effort on human well-being — the Person-to-Person Health Interview Study — and includes specific measurement batteries for ego-centric data collection.