Sixteen soybean [Glycine max (L.) Merr.] cultivars were evaluated for their response to the rice herbicide propanil (3′,4′,-dichloropropionanilide) applied at two growth stages. Application of 3.4 kg/ha resulted in more injury than 0.6 kg/ha. Application at the stage of growth when three nodes on the main stem had completely unrolled leaves (V3) resulted in more injury than when eight nodes had completely unrolled leaves (V8). As determined by seed yield when treated at 3.4 kg/ha propanil at the V3 stage of growth, ‘Pickett 71′, ‘McNair 600′, ‘Tracy’, and ‘Bragg’ were the most tolerant; ‘Hutton’, ‘Hampton 266A’, ‘Bossier’, ‘Ts 74-34′, ‘Semmes', and ‘Forrest’ were moderately sensitive and Dowling’, ‘Davis', ‘Mack’, ‘Dare’, ‘Ranson’, and ‘McNair 800’ were the most sensitive to propanil injury.