With the onset of the COVID-19 pandemic in the United States, many state and local governments were forced to implement necessary policies to contain transmission of the deadly virus. These policies ranged from closing most businesses to more controversial proposals, such as postponing primary elections. In this research note, we examine the role that scientific knowledge and gender played in citizen perceptions of these virus containment policies, both in the general population and among partisans. We find that while a gender gap persists in scientific knowledge, both in the general population and within the parties, women are generally more likely to use this knowledge to inform their policy views on necessary government action during the COVID-19 pandemic. These findings shed light on how knowledge and gender intersect to drive support for government intervention during the time of a severe public health crisis in a partisan America.