Interest groups cannot advocate on every issue they might consider relevant. They must decide what issues to prioritise and which ones to leave to one side. In this article, we examine how groups seek to balance different internal and external considerations when prioritizing issues, and which factors might explain variation in the relative strength of these drivers. We integrate data of a survey of national interest groups in Australia with findings from interviews with a cross section of high-profile groups. While the literature often suggests a clash between external political considerations and internal membership demands, we find that groups view these drivers as largely compatible. Our explanatory analysis points to the policy orientation and insider status of the group, its democratic character, and the extent to which it faces competition for membership contributions, as important factors shaping the relative strength of distinct drivers of internal agenda setting.