Empathy involves being able to understand and respond to others’ emotional experiences. Whilst deficits in empathy have been observed in frontotemporal dementia, the extent to which empathy is disrupted in dementia syndromes with predominant language impairment remains unclear. The current study investigated cognitive and affective empathy in the two non-fluent primary progressive aphasia syndromes: progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (LPA). Informants of 23 PNFA and 16 LPA patients completed the Interpersonal Reactivity Index (IRI), regarding patients’ capacity for empathy pre- and post-disease onset. Twenty-four healthy control participants completed the self-rated IRI for comparison of post-disease empathy capabilities. Within-group analyses revealed reduced cognitive empathy and increased personal distress in both patient groups. In addition, lowered affective empathy was reported in PNFA, with a similar trend observed in LPA. Interestingly, reduced affective empathy was associated with greater carer burden in LPA. Between-group analyses revealed reduced cognitive empathy in both patient groups relative to controls. The current study is the first to document empathy changes in PNFA and LPA, offering insight into the social cognitive deficits experienced in these syndromes. Future neuroimaging studies are needed to identify the underlying neural correlates and mechanisms driving empathy deficits in PNFA and LPA.

The Interpersonal Reactivity Index (IRI) is a multidimensional individual-difference measure of empathy. The original IRI has been used in many studies to assess both normal and clinical samples. Because of its wide availability and convenience of use, the IRI has been translated into several languages. In Taiwan, the IRI was translated into traditional Chinese as a Chinese Version of the Interpersonal Reactivity Index (C-IRI) in 1987. Because the C-IRI was developed over 26 years ago and recent studies have shown some unsatisfactory psychometric properties on the C-IRI, there was a need to develop an alternative to the C-IRI and verify its psychometric properties again. In this study, we assessed the psychometric properties of an alternative C-IRI by administering it to 516 college students, 35 community residents and 70 schizophrenic patients, all of whom are adults. Exploratory factor analyses revealed a four-factor structure: Fantasy, Perspective Taking, Empathy and Personal Distress. Acceptable convergent and divergent validity supported the construct validity of the alternative C-IRI. Evidence was also found for its discriminant validity between patients with schizophrenia and normal controls on the Empathy subscale and Affective Empathy, while the full scale and its factors demonstrated good internal consistency and test–retest reliability. In the future, the alternative C-IRI should be validated with adolescent or elderly samples, and different clinical samples.