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A 44-year-old gravida 2, para 2 presents for evaluation of a four-month history of intermenstrual bleeding. Menses occur at regular, 28-day intervals, and last 4–5 days with recently heavy flow. For the past four months she has had painless intermenstrual bleeding at unpredictable times throughout her cycle. Intermenstrual bleeding ranges from spotting to moderate flow and lasts one to two days. Her last menstrual period was three weeks ago. She is up to date on cervical cancer screening and routine gynecologic care. Medical history is significant for hypothyroidism, two prior cesarean deliveries, and bilateral tubal ligation. She is on levothyroxine and denies any medications allergy. She is sexually active with one male partner and denies any history of sexually transmitted infections or recent exposures.
Perimenopause is the time in a woman's life when she begins to experience the changes that lead to menopause. Smoking and shorter menstrual cycles can cause earlier menopause, while multigravidity and use of oral contraceptive pills are associated with later menopause. There may be additional factors, including cultural differences that influence the age of menopause. The menstrual and urogenital changes associated with perimenopause can be very distressing. Menstrual patterns are altered in many ways, including menorrhagia, menometrorrhagia, oligomenorrhea, intermenstrual bleeding, polymenorrhea, postcoital bleeding, and postmenopausal bleeding. In one small survey, 93% of women reported one of these changes in the five years prior to menopause. The challenge for the provider is to distinguish between normal and abnormal bleeding. Ultrasonography has become the standard test in the evaluation of dysfunctional uterine and postmenopausal bleeding. Hysterectomy is the only way to stop menorrhagia completely.
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