The recently introduced two-parameter infinitely-many-neutral-alleles model extends the celebrated one-parameter version (which is related to Kingman's distribution) to diffusive two-parameter Poisson-Dirichlet frequencies. In this paper we investigate the dynamics driving the species heterogeneity underlying the two-parameter model. First we show that a suitable normalization of the number of species is driven by a critical continuous-state branching process with immigration. Secondly, we provide a finite-dimensional construction of the two-parameter model, obtained by means of a sequence of Feller diffusions of Wright-Fisher flavor which feature finitely many types and inhomogeneous mutation rates. Both results provide insight into the mathematical properties and biological interpretation of the two-parameter model, showing that it is structurally different from the one-parameter case in that the frequency dynamics are driven by state-dependent rather than constant quantities.

The stationary version of the infinitely many neutral alleles diffusion model, as studied by Ethier and Kurtz, is constructed and analyzed using the theory of Dirichlet forms. We prove that the ‘boundary' of the state space is hit by the process iff θ < 1, where θ is the mutation parameter.

A Markov chain model of a population consisting of a finite or countably infinite number of colonies with N particles at each colony is considered. There are d types of particle and transition from the nth generation to the (n + 1)th is made up of three stages: reproduction, migration, and sampling. Natural selection works in the reproduction stage. The limiting diffusion operator (as N→∞) for the proportion of types at colonies is found. Convergence to the diffusion is proved under certain conditions.

We propose a model of a passive nerve cylinder undergoing random stimulus along its length. It is shown that this model is approximated by the solution of a stochastic partial differential equation. Numerous properties of the sample paths are derived, such as their modulus of continuity, quadratic and quartic variation, and it is shown that the solution exhibits the phenomenon of flicker noise. The first-passage problem is studied, and it is shown to be connected with a first-hitting time for an infinite-dimensional diffusion.