The response of 22 potato (Solanum tuberosum L.) cultivars to soil-incorporated and foliar applications of metribuzin [4-amino-6-tert-butyl-3-(methylthio)-as-triazin-5(4H)one] at rates of 0.5 and 1.0 kg ai/ha, was evaluated in field experiments from 1979 to 1982. Metribuzin significantly reduced the yield of marketable tubers in several potato cultivars. Foliar applications generally resulted in more injury than soil applications. Yields were reduced primarily through stand reduction and a decreased number of tubers per plant. Neither tuber size nor specific gravity of tubers was significantly reduced in the cultivars studied. The most susceptible cultivar was ‘Alaska Red’, followed by ‘Rhine Red’, F72117, ‘Caribe’, and ‘Shepody’. Other cultivars evaluated were highly tolerant to metribuzin, irrespective of rate or method of application. There was an increase in hollow heart in cultivars ‘Atlantic’ and ‘Lemhi Russet’ following treatment with metribuzin.