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Infective endocarditis (IE) is a disease of the endocardial surface of the heart, native or prosthetic heart valves or intracardiac cardiac devices with an estimated annual incidence ranging from 3 to 14 per 100.000 person-years. The causes and epidemiology have changed in recent decades due to the growing number of health-related procedures and lower incidence of rheumatic heart disease. Although IE is a rare cause of stroke, this is the most common neurological complication of IE, affecting up to 35% of all patients. Risk factors for brain embolization include vegetation size and mobility, left-side vegetation and a Staphylococcus aureus infection. We present a 41 year-old man with a history of heroin and cocaine use and chronic liver disease (alcoholic and hepatitis C virus), who presented with stroke and was diagnosed with infective endocarditis
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