This article discusses briefly a category of New Testament manuscripts with ‘hermeneiai’ before offering a critical edition of P.CtYBR inv. 4641, a Coptic codex leaf containing portions of the text of John that was recently discovered by the present author in the Beinecke Rare Book and Manuscript Library, Yale University. Unidentified until now, this codex leaf represents the first known example of a hermeneia manuscript of John written solely in Coptic. As such, the Yale fragment has much significance for discussions about the ἑρμηνεία manuscripts, their origin, influences and functions.