Soil application of herbicides for preemergence (PRE) weed control in grain sorghum is vital to control weeds. Efficacy of soil-applied herbicides is impacted by herbicide adsorption which is influenced by soil organic matter (SOM) and texture. With precision agriculture technologies, variable rate applications (VRA) can be utilized to maximize herbicide effectiveness. In 2016, algorithms were developed for two locations to use VRA of two tank mixed herbicides based on SOM and soil electrical conductivity (EC) collected by a Veris MSP3 system. Drone imagery provided an effective way to evaluate the efficacy of herbicide applications along with visual assessment. VRA applications of herbicide tank mixes provided equal weed control compared to flat rate applications.