This paper presents a high-order sliding mode approach to design variable structure controllers for nonlinear multivariable cross-coupling systems whereby a change in either control input affects the control loops of all the subsystems dynamics. A hybrid-sliding mode control (hybrid-SMC) scheme is constructed combining a new equivalent control algorithm with a high-order discontinuous control algorithm to benefit from the advantages of both control strategies. The hybrid-SMC scheme uses weighting coefficients to weight and combine controllers. The equivalent control algorithm uses a relative degree concept through dynamic constraints imposed on the sliding variables to overcome the limitations of the conventional approaches and to provide an optimum tracking performance. A scale-laboratory helicopter model is used to sum up the main features and demonstrate the effectiveness of the developed control scheme. The proposed hybrid-SMC strategy is compared to existing sliding mode-based control approaches in terms of tracking performance, stability and control efforts. The obtained results demonstrate the validity and efficiency of the proposed hybrid-SMC scheme.