Longspine sandbur is a troublesome weed infesting corn in the Great Plains. However, herbicides are now available to control this species. This study characterized longspine sandbur ecology in irrigated corn to aid producers in integrating herbicides into their production systems. Longspine sandbur began emerging May 25, and by June 15, 84% of the seasonal emergence had occurred. Plant development was related to cumulative growing degree days. Seeds were viable early in longspine sandbur's development, with 20% of seeds viable by heading. Producers can minimize seed production of longspine sandbur in field borders by mowing plants at the boot stage. Bur production per plant was related to time of emergence, with seedlings emerging in late May producing 1,120 burs per plant. Seedlings emerging 4 wk later produced 84% fewer burs. Controlling longspine sandbur before 4 wk of interference prevented loss of corn grain yield.