Field studies were conducted in 1999, 2000, and 2001 to determine the effectiveness of mesotrione applied preemergence (PRE) or postemergence (POST) in no-till corn. Also, a proposed prepackage mix of mesotrione plus acetochlor (1:11 ratio of mesotrione–acetochlor) in combinations with the trimethylsulfonium salt of glyphosate (glyphosate-TMS), paraquat, and 2,4-D was investigated. Mesotrione PRE at 235 g ai/ha or greater controlled common lambsquarters, smooth pigweed, and common ragweed at least 80%. POST mesotrione at 35 g/ha and higher controlled common lambsquarters 91% or greater. Mesotrione applied POST at 140 g/ha controlled smooth pigweed greater than 97%. Common ragweed control from POST mesotrione was inconsistent, ranging from 56 to 97%. PRE and POST applications of mesotrione did not adequately control goosegrass, giant foxtail, fall panicum, johnsongrass, or cutleaf eveningprimrose. The mesotrione plus acetochlor prepackage mix plus glyphosate-TMS or paraquat controlled field pansy and ivyleaf morningglory similar to or better than did the prepackage mixture of the isopropylamine salt of glyphosate (glyphosate-IPA) plus atrazine plus acetochlor. But common ragweed control by mesotrione plus acetochlor plus glyphosate-TMS or paraquat was occasionally lower than control by the prepackage mixture of glyphosate-IPA plus atrazine plus acetochlor. Corn injury was generally less than 10% with PRE and POST mesotrione applications.