We provide an overview of transnational non-state actors and their agency that shape today’s out-of-home childcare around the world, specifically institutional residential childcare. Based on existing studies and desktop research, we reveal a broad range of complexly inter-related for-profit and non-profit actors promoting diverse, often conflicting policies and practices – with ambiguous implications for children in care. We focus on secular and faith-based international non-governmental organisations, transnational companies, private regulators, and individuals. Many of them promote family- and community-based care, yet many others support orphanages and other forms of institutional care. The growing number of transnational actors in residential childcare, the emergence of private regulatory frameworks, the advance of market-based, for-profit players, and the involvement of well-resourced religious communities make the future of child institutionalisation uncertain. We discuss how this transnational agency compares with other policy fields and propose directions for future investigations of how transnationalism impacts children in care.