Mine closure can be approached by several points of view, from the technical, engineering, ecological, up to social and governance aspects. The definition of a good mine closure should cover most, if not all, of these aspects. This article provides a review of technical and engineering-oriented research work as a partial answer to the question ‘what is good mine closure’. The article presents a ten-year research program realized in the framework of a Canada Research Chair in integration of environment in the mine life cycle. Research projects aimed at better planning mine closure and mine site reclamation from the early stages of a mining project life cycle are exposed as possible steps to strive for optimal mine waste management. At the exploration stage, geo-environmental characterization and modeling are proposed as tools to improve mine waste management planification. During mine operations, environmental desulfurization is suggested as a method to reduce environmental risks associated with sulfidic tailings and waste rock. Indeed, research has shown that acid mine drainage and metal leaching can be significantly limited via desulfurization. At the closure stage, desulfurized tailings can be used to replace at least part of natural materials used for reclamation cover systems. Research work done on other types of mine waste, such as waste rock and water treatment sludge, also show good potential for their reuse as closure material. All these tools can be integrated into the mine life cycle to better plan for closure, which ultimately will make mine closure more sustainable.