Chapter 5 analyses how, in the context of the international isolation of Francoist Spain in the early 1940s, autarchic discourses and projects for economic and industrial self-sufficiency gained prominence and guided the new policies. Raw materials, the way they were geographically distributed and the economics of their exploitation became state decisions to which chemists contributed in reframing academic disciplines and industrial endeavours. This chapter also stresses the distinction between autarky (referring to economic self-sufficiency) and autarchy (referring to autocratic political rule). Under the influence of fascist Italy and Nazi Germany, chemicals became important agents for the materialisation of the early Francoism. Industrial chemistry training evolved from the traditional technical chemistry books and subjects to a more ‘modern’ approach to chemical engineering. Finally, chemical diplomacy and chemists’ active role as ‘ambassadors’ of the regime provide additional reasons to revisit autarky/autarchy, as well as pointing out some lines of continuity with the scientific culture of the pre-Civil War period.