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1 results

  • Chapter 16 - What Science May Come for Embryo Selection?

  • Edited by Catherine Racowsky, Hôpital Foch, France, Jacques Cohen, IVF 2.0, New York, Nicholas Macklon, London Women's Clinic
  • Book:
    Manual of Embryo Selection in Human Assisted Reproduction
    Published online:
    26 April 2023
    Print publication:
    26 January 2023, pp 168-176

  • Summary

    The success of artificial reproductive technologies (ART) requires effective methods for selecting embryos with optimal potential for generating a live birth. A glimpse into the landscape of future of ART reveals a field replete with breakthrough opportunities. In the context of the current pace of scientific discovery and technological development, we can expect the development of different novel technologies for gametes and embryo selection. Among these new technologies we can envision embryo selection technologies based on metabolic markers; the use of artificial intelligence and deep learning; non-invasive, label-free microscopy; and cell-sorting techniques for sperm selection. It is also likely that embryos will be scored based on the relative activation of stress-pathways; embryos showing an intermediate, “Goldilocks” level of stress will be preferentially selected. Overall, it will be important to thoughtfully consider and discuss the ethical implications of new technologies that could be used in ART.