I review observational studies of the large-scale star formation process in nearby galaxies. A wealth of new multi-wavelength data provide an unprecedented view on the interplay of the interstellar medium and (young) stellar populations on a few hundred parsec scale in 100+ galaxies of all types. These observations enable us to relate detailed studies of star formation in the Milky Way to the zoo of galaxies in the distant universe. Within the disks of spiral galaxies, recent star formation strongly scales with the local amount of molecular gas (as traced by CO) with a molecular gas depletion time of ∼2 Gyr. This is consistent with the picture that stars form in giant molecular clouds that have about universal properties. Galaxy centers and star-bursting galaxies deviate from this normal trend as they show enhanced star formation per unit gas mass suggesting systematic changes in the molecular gas properties and especially the dense gas fraction. In the outer disks of spirals and in dwarf galaxies, the decreasing availability of atomic gas inevitably limits the amount of star formation, though with large local variations. The critical step for the gas-stars cycle seems therefore to be the formation of a molecular gas phase, a process that shows complex dependencies on various environmental properties and is being investigated by intensive simulational work.