Voters use salient issues to inform their vote choice. Using 2020 Cooperative Election Study (CES) data, we analyze how short-, medium-, and long-term issues informed the vote for president in the 2020 election, which witnessed record-setting participation. To explain the dynamics of presidential vote choice, we employ a voter typology advanced by Key (1966). Specifically, compared to standpatters, who in 2020 registered the same major party vote as in 2016, we find that new voters in 2020 and voters switching their preferences from 2016 cast their ballots in favor of Democrat Joe Biden. In the end, President Donald Trump was denied reelection by new voters and vote switchers principally because certain issues had a notable effect in moving their presidential preferences in the Democratic direction.