This chapter reviews the neuroanatomy and neurochemistry of frontal-subcortical circuits (FSCs) and outlines the signature syndromes of FSC circuit dysfunction. The oculomotor circuit originates in the frontal eye field as well as prefrontal and posterior parietal cortex and connects sequentially to the central body of the caudate nucleus, dorsomedial GP interna (GPi) and ventrolateral SN pars reticulata (SNr), ventral anterior and medial dorsal thalamic nuclei, and back to the frontal eye field. Emotional, motivational, and affective information processed by the basal ganglia is represented in the rostromedial limbic circuitry arising from the orbital and medial prefrontal cortex. Processing of the detailed information contained in the FSCs is modulated by input from dopaminergic, cholinergic, noradrenergic, and serotonergic systems. The orbitofrontal (OF) cortex is the neocortical representation of the limbic system and involved in the determination of the appropriate time, place, and strategy for environmentally elicited behavioral responses.