We examine the impact of economic development and the role of political alignment on the fatalities and damages due to floods using state-level panel data for 19 Indian states over the period 1980–2011. The empirical results confirm that economic development leads to a decline in flood fatalities and damages due to floods across Indian states. This study also examines the role of politics in the prevention of flood fatalities. We find that both state election years and political alignment influence the extent of flood fatalities. The results suggest that not only economic development but also healthy political coordination between the central government and the states is essential to mitigate the impact of floods.