The Almogholagh–Dehgolan region is in the North Sanandaj–Sirjan zone of NW Iran. The granites of the region are metaluminous and display geochemical and textural characteristics of transitional granites between ferroan (A-type) and I-type granites. In geotectonic discrimination diagrams, the Almogholagh–Dehgolan granites plot mainly in the fields of within-plate granites and volcanic arc granites. With the exception of the Qalaylan granites, parts of other granites resemble A2-type granites. Granites of the Qalaylan intrusive body have petrographic and geochemical features close to I-type granites and are not A-type. Primary mantle and chondrite-normalized spider diagrams show enrichments in light rare earth elements relative to heavy rare earth elements. For an age of 150 Ma, the initial 87Sr/86Sr and 143Nd/144Nd ratios vary from 0.702769 to 0.706545 and from 0.512431 to 0.512558, respectively. Epsilon Nd values vary in a relatively limited range between −0.3 and +2.2, which corresponds to a mixed mantle–crustal source. On the basis of new geochemical and isotopic data, we suggest a geodynamic model involving partial melting of lower crustal rocks with the contribution of mantle magmas in a weakly extensional tectonic setting for the generation of the A-type granites of the region. The occurrence of ferroan (A-type) granites in this region of the Sanandaj–Sirjan zone indicates the existence of a partly extensional tectonic environment in a mainly compressional subduction-related regime in Late Jurassic time.