Physical activity has been linked to positive health outcomes for frail seniors. However, our understanding of factors that influence the physical activity of residents in the long-term care (LTC) setting is limited. This article describes our work with focus groups, one component of a multi-component study that examined factors influencing the physical activity of LTC residents. Residents, significant others, and staff from nine LTC facilities participated in these focus groups. Analysis of group discussions revealed three themes reflecting factors that mitigate the provision of physical activity: (a) inadequate support for physical activity, (b) pervasive institutional routines, and (c) physical environment constraints. All participants considered physical activity important to health preservation. Individual, structural, and environmental factors affected the quantity and quality of physical activity accessed by residents. These findings confirm the need to develop practical strategies and ways to address modifiable barriers and embed physical activity into LTC systems of care.