While the most commonly employed burnout measure has been the Maslach Burnout Inventory (MBI), researchers have been troubled by some of the psychometric limitations of this instrument. The aim of this study was to analyze the psychometric properties of the “Spanish Burnout Inventory” (SBI). The psychometric properties were analysed with data from a sample of 277 Chilean professionals working to physical disabled people. The psychometric properties of the SBI were examined through the following analyses: confirmatory factor analysis, reliability Cronbach's alpha, and concurrent validity with the MBI. The hypothesized four factor model obtained an adequate data fit for the sample (X2(164) = 285.32, p < .001, GFI = .96, RMSEA = .052, NNFI = .93, CFI = .94). Results confirmed the hypothesis formulated. The Cronbach's alpha coefficient was higher than .70 for the four scales of the instruments. Results supported the concurrent validity with the MBI. As a whole, the results of these study provided evidence on the adequate psychometric properties of the SBI for the study of burnout in the Chilean cultural context.