Integrating the visual navigation mechanism of flying insects with a nonlinear Kalman filter, this paper proposes a novel navigation algorithm. New concepts of entropic map and entropy flow are presented, which can characterize topographic features and measure changes of the image respectively. Meanwhile, an auto-selecting algorithm of assessment threshold is proposed to improve computational accuracy and efficiency of global motion estimation. The simulation results suggest that the navigation algorithm can perform real-time rectification of the missile's trajectory well, and can reduce the cost of the missile's hardware.