Tall fescue toxicosis adversely affects calving rate and weight gainsreducing returns to cow-calf producers in the south–central United States.This grazing study estimated animal and economic performance implications ofendophyte-infected fescue and calving season. Establishing novelendophyte-infected tall fescue on 25% of pasture acres resulted in improvedcalving rates (87% vs. 70%), weaning weights (532 lbs vs. 513 lbs), andpartial returns per acre ($257 vs. $217). Additionally, fall-calving cowshad higher calving rates (91% vs. 67%), weaning weights (550 lbs vs. 496lbs), and partial returns per acre ($269 vs. $199) than spring calvingcows.