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  • 25 - Cell replacement in spinal cord injury

  • from Section B3 - Promotion of regeneration in the injured nervous system
    • By Itzhak Fischer, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Angelo C. Lepne, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Steve Sang Woo Han, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Alan R. Tessler, Department of Neurobiology and Anatomy, Drexel University College of Medicine and Department of Veterans Affairs Hospital, Philadelphia, PA, USA
  • Edited by Michael Selzer, University of Pennsylvania, Stephanie Clarke, Université de Lausanne, Switzerland, Leonardo Cohen, National Institute of Mental Health, Bethesda, Maryland, Pamela Duncan, University of Florida, Fred Gage, Salk Institute for Biological Studies, San Diego
  • Book:
    Textbook of Neural Repair and Rehabilitation
    Published online:
    05 March 2012
    Print publication:
    16 February 2006, pp 445-467

  • Summary

    This chapter summarizes pioneering work on neural tissue transplantation that showed the feasibility of cell replacement as a treatment for spinal cord injury (SCI). It focuses on neural transplants with emphasis on the potential for neural stem cells (NSCs) and lineage-restricted precursors to replace damaged neurons and glia and to enhance regeneration. NSC has been identified not only in the fetal central nervous system (CNS), but also at later stages of CNS development and in select regions of the brain and spinal cord throughout adult life. The chapter present results of their transplantation into the spinal cord with respect to issues of fate, potential therapeutic properties and problems that need to be solved. It considers strategies for activating endogenous stem cells in the adult spinal cord for repair. Finally, the chapter reviews experimental strategies for cellular replacement in traumatic injury.