How was Chinese people’s confidence in the political system linked to their perception of Covid infection risk, perception of health threat of Covid infection, lockdown experience, and attitudes toward the dynamic Zero-Covid policy? Using 2 waves of online surveys conducted in 2020 and 2022, we investigated how these factors were related. Individuals who were more supportive of the Zero-Covid policy were more confident. Those who were less supportive of the Zero-Covid policy were from areas with more severe Covid infections and experienced a longer lockdown as well; these individuals also perceived higher Covid infection risk and health threat. As such, their confidence in the political system was also more likely to drop from 2020 to 2022. In sum, these findings suggest that Chinese people’s confidence in the political system was linked to their Covid infection risk perception, perceived Covid threat to health, lockdown experience, and attitudes toward the Zero-Covid policy. These findings were corroborated with the severity of Covid infections in the province and individual’s political beliefs and orientation.