Although Palmer amaranth is currently not widespread in most dry edible bean−producing states in the United States, it is widespread in western Nebraska, a major dry edible bean−producing region. There is currently a lack of research on management and biology of Palmer amaranth within dry edible bean production. The objective of this study was to quantify the impact of season-long Palmer amaranth interference on yield of dry edible bean and seed production of Palmer amaranth. A field study was conducted in Scottsbluff, NE, in 2020 and 2021. Palmer amaranth interference at densities of 0, 0.2, 0.3, 0.5, 1, and 2 plants m−1 row of dry edible bean was evaluated. Palmer amaranth interference reduced dry edible bean yield by 77% at a weed density of 2 plants m−1 row compared to the weed-free control, and a 5% yield reduction threshold was estimated to occur at a Palmer amaranth density of 0.02 plants m−1 row. Yield reduction occurred primarily through a reduction in the number of pods per plant as Palmer amaranth density increased. Palmer amaranth plants produced 91,000 to 376,000 seeds per plant depending on densities, and as many as 140,000 seeds m−2. Study results will help farmers and other stakeholders estimate Palmer amaranth interference within their fields, and may help justify the economic cost of incorporating additional Palmer amaranth management practices.