This article explores the role of the Little Mothers’ Leagues in New York City, clubs created by public health authorities to educate working-class girls as young as eight years old who took care of their younger siblings while their parents worked. The Little Mothers’ Leagues served as an essential link between social reform and eugenic public health programming during the first two decades of the twentieth century. Eugenic maternalism, as articulated by the Little Mothers’ Leagues, distilled a sense of Americanness into a set of hygienic practices and rituals that could be easily understood and imitated. Through the Little Mothers’ Leagues, eugenic maternalist reformers addressed essential questions regarding the role of social reform in the “Americanization” process, the role of young girls as citizens and as entry points to the immigrant home, and the extent to which environmental reform could regulate the immigrant family. Examining the Little Mothers’ Leagues as a project that was both eugenic and maternalist allows us to better understand the ways that eugenic thinking permeated popular discourse through child welfare reform and domestic science.