Root uptake and translocation of nitrofluorfen [2-chloro-1-(4-nitrophenoxy)-4-(trifluoromethyl)benzene] and oxyfluorfen [2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene] were measured in fababean (Vicia faba L.) and green foxtail [Setaria viridis (L.) Beauv.] plants, and metabolism was studied using fababean leaf discs and green foxtail leaf segments. Both herbicides were taken up readily from nutrient solution but translocation was limited. In fababeans, 4.6% of the nitrofluorfen label was translocated to the shoot as compared to 2.2% of the oxyfluorfen label. Less than 10% of the nitrofluorfen or oxyfluorfen taken up in vitro was metabolized after 24 h. This rate of metabolism would not likely influence the herbicidal action of either herbicide.