Field studies were conducted in 1996 and 1997 to evaluate response of eight peanut cultivars to diclosulam applied preplant incorporated at 36 g ai/ha in a weed-free environment. Peanut cultivars evaluated included ‘NC 12C’, ‘NC 7’, ‘VAC 92R’, ‘NC-V 11’, ‘NC 10C’, ‘AT VC 1’,‘NC 9’, and the experimental breeding line N90010E. Visible injury 3 wk after planting was less than 5% regardless of cultivar. No injury was observed at 21 d after planting. Diclosulam did not influence the incidence of early leaf spot, late leaf spot, southern stem rot, cylindrocladium black rot, or tomato spotted wilt virus. Diclosulam did not affect percentage of extra large kernels, sound mature kernels, other kernels, and yield.