If available for use on snap bean, pyroxasulfone would provide valuable preemergence control of troublesome weed species that currently contaminate the crop postharvest. The extent to which snap bean tolerates pyroxasulfone is poorly documented. The objective of this research was to quantify the extent to which pyroxasulfone tolerance exists in a large collection of snap bean cultivars. A snap bean diversity panel of 277 entries was screened for tolerance to sulfentrazone at a rate of 420 g ai ha−1 in a field trial in 2019 and 2020 near Urbana, IL. Snap bean cultivars exhibited variation in tolerance to pyroxasulfone. While a handful of cultivars were tolerant across variable environments, most cultivars were sensitive in the year that had 30% more water supply (rainfall plus sprinkler irrigation) within 3 wk of planting. Low estimates of broad-sense heritability reflect a large influence of the environment on seedling emergence and growth. With a few exceptions, currently, the margin of crop safety across diverse germplasm is insufficient for registration of pyroxasulfone use on snap bean crops.