Sustainable production systems are needed to maintain soil resources and reduce environmental contamination on erodible lands that are incompatible with tillage-intensive operations. A long-term cropping systems comparison was established at Beltsville, Maryland, on a site with 2 to 15% slope to evaluate the efficacy of sustainable strategies compatible with reduced-tillage systems. All systems followed a 2-year rotation of corn the first year and winter wheat followed by soybean the second year. Treatments included (1) no-tillage system with recommended fertilizer and herbicide inputs, (2) crownvetch living mulch system with similar inputs to the no-tillage system, (3) cover crop system including a hairy vetch cover crop before corn and a wheat cover crop before soybean with reduced fertilizer and herbicide inputs, and (4) manure system including crimson clover green manure plus cow manure for nutrient sources, chisel plow/disk for incorporating manure, and rotary hoe plus cultivation for weed control. Results from the initial 4 years demonstrated the relative productivity of these systems. Corn yields were similar in the no-tillage and cover crop systems in each year; both systems averaged 7.8 Mg ha-1 compared to 5.7 Mg ha-1 in both the crownvetch and manure systems. Wheat yields were highest in the manure system in the first 2 years and in the crownvetch system in the last 2 years. Soybean yields were highest in the cover crop system in all years. The manure system usually had lower yields than the highest yielding systems, partly because of competition from uncontrolled weeds. Several measures of the efficiency of grain production were evaluated. The no-tillage system produced the most grain per total vegetative biomass throughout the rotation. The cover crop system produced the most grain per unit of external nitrogen input and, along with the no-tillage system, had the highest corn water-use efficiency. The cover crop system also recycled the most vegetative residues and nutrients of all systems. No single system performed best according to all measures of comparison, suggesting that trade-offs will be required when choosing production systems.