Crambe has gained interest as an alternative crop for industrial oil production. No herbicides are currently registered in crambe and weed control strategies need to be identified if crambe is to become a viable crop. Field experiments were conducted to determine crambe tolerance to several herbicides. Crambe was tolerant to soil-applied trifluralin, pendimethalin, and cinmethylin, or DPX-A7881 applied postemergence. Postemergence applications of chlorimuron or imazethapyr were injurious to crambe.