Cover crop adoption is increasing among growers with the occurrence of herbicide-resistant weed species. A field study conducted at three sites from autumn 2021 through the crop harvest in 2022 in Alabama aimed to evaluate the combined effect of cover crop residue and herbicides for weed control and improved cotton lint yield. The experiment was conducted in split-plot design with main plots consisting of six cover crop treatments: cereal rye, crimson clover, oat, radish, cover crop mixture, and winter fallow. The subplots included four herbicide treatments: (i) preemergence, pendimethalin + fomesafen, (ii) postemergence, dicamba + glyphosate + S-metolachlor, (iii) preemergence followed by postemergence, and (iv) nontreated (NT) check. Cover crops, excluding radish, exhibited greater weed biomass reduction than winter fallow with corresponding herbicide treatments of either preemergence, postemergence, or preemergence + postemergence as compared to control (winter fallow and NT check). Considering preemergence + postemergence treatment, cereal rye, crimson clover, oat, and cover crop mixture provided >95% weed biomass reduction as compared to control. Looking at the overall effect of cover crop, cereal rye outperformed and showed greater weed biomass reduction than radish relative to control. Preemergence + postemergence herbicide treatment resulted in greater lint yield than other treatments. Cotton in cereal rye plots had a greater lint yield than in winter fallow at one out of three locations. In conclusion, integrating herbicides and incorporating high-residue cover crops such as cereal rye is an effective weed management strategy to control troublesome weeds.