POST control of cowpea in cotton was evaluated in 1990 and 1991. Early POST-directed (EPD) application of fluometuron + MSMA provided 89% cowpea control 2 wk after treatment. Cowpea control 4 wk after the early treatments was similar with fluometuron + MSMA EPD and sequential directed applications of MSMA followed by (fb) MSMA, methazole + MSMA fb cyanazine + MSMA, and fluometuron + MSMA fb cyanazine + MSMA. The average reduction in cowpea biomass 12 wk after planting with these treatments was 93%. MSMA fb MSMA POST-directed was the only treatment with a lint cotton yield similar to that of weed-free cotton. Lint cotton yields with fluometuron + MSMA, methazole + MSMA fb cyanazine + MSMA, and fluometuron + MSMA fb cyanazine + MSMA were similar to those obtained with MSMA fb MSMA.