Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

4 results

  • The use of neutrophil–lymphocyte ratio for the prediction of refractory disease and coronary artery lesions in patients with Kawasaki disease

  • Juan S. Farias, Enrique G. Villarreal, Fabio Savorgnan, Sebastian Acosta, Saul Flores, Rohit S. Loomba
  • Journal:
    Cardiology in the Young / Volume 33 / Issue 8 / August 2023
    Published online by Cambridge University Press:
    04 April 2023, pp. 1409-1417
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation
  • Background:

    Kawasaki disease is a vasculitis that can lead to cardiac complications, including coronary artery disease and cardiogenic shock. Various scoring systems have been developed to determine those that will be refractory to routine intravenous immunoglobulin therapy or develop coronary artery disease. The objective of this study was to determine if the neutrophil–lymphocyte ratio could predict refractory disease and coronary artery lesions in patients with Kawasaki disease.

    Methods:

    A systematic review of the literature was performed to identify manuscripts describing comparisons of neutrophil–lymphocyte ratio between those who had refractory disease and those who did not, and between those who developed coronary artery lesions and those who did not. Mean difference was compared between groups. Areas under the curve were utilised to determine the pooled area under the curve.

    Results:

    12 studies with 5593 patients were included in the final analyses of neutrophil–lymphocyte ratio for the prediction of refractory disease. Neutrophil–lymphocyte ratio before therapy was higher in refractory disease with a mean difference of 2.55 (p < 0.01) and pooled area under the curve of 0.724. Neutrophil–lymphocyte ratio after therapy was higher in refractory disease with a mean difference of 1.42 (p < 0.01) and pooled area under the curve for of 0.803. Five studies with 1690 patients were included in the final analyses of neutrophil–lymphocyte ratio for the prediction of coronary artery lesions. Neutrophil–lymphocyte ratio before therapy was higher in coronary artery lesions with a mean difference of 0.65 (p < 0.01).

    Conclusion:

    The use of neutrophil–lymphocyte ratio may help physicians in the identification of patients at risk of refractory disease and coronary artery lesions in patients with Kawasaki disease.

  • Chapter 46 - Kawasaki Disease

  • from Section 7 - Miscellaneous Lesions and Syndromes
  • Edited by Laura K. Berenstain, James P. Spaeth
  • Book:
    Congenital Cardiac Anesthesia
    Published online:
    09 September 2021
    Print publication:
    16 September 2021, pp 352-358

  • Summary

    Kawasaki disease is a generalized vasculitis of unknown etiology affecting children. Although self-limited in most cases, the disease can cause coronary artery abnormalities, including coronary aneurysms. These are more frequently seen in untreated children but can also occur in those who received appropriate therapy at the time of diagnosis. The coronary artery abnormalities can resolve or persist. Those that persist can lead to coronary stenosis, thrombotic occlusion, or rarely, rupture, resulting in myocardial infarction, the primary cause of death in these children. Affected patients require close follow up for cardiac surveillance, which frequently involves the need for advanced cardiovascular imaging studies. Given their young age, sedation or general anesthesia is required in most cases. Management requires a thorough understanding of the pathophysiology of the disease process, particularly the cardiac manifestations of the condition, along with knowledge of the effects of the various anesthetic agents on hemodynamics and ventricular function.

  • Coronary aneurysms, myocardial dysfunction, and shock in a COVID-19 child, role of ECMO, immunomodulation, and cardiac CT

  • Part of
  • Muhammad R. Mustafa, Michael J. Carter, James Wong, Aaron Bell, Caner Salih
  • Journal:
    Cardiology in the Young / Volume 31 / Issue 6 / June 2021
    Published online by Cambridge University Press:
    28 January 2021, pp. 1043-1047
    • Article
      • You have access
      • Open access
    • PDF
    • HTML
    • Export citation

  • Coronary artery aneurysms in children were observed as a rare complication associated with coronavirus disease 2019 (COVID-19). This case report describes the severe end of the spectrum of the new multisystem inflammatory syndrome in a 12-year-old child with coronary aneurysms, myocardial dysfunction, and shock, managed successfully with extracorporeal membrane oxygenation support and immunomodulation therapy. This report also highlights the additional benefits of cardiac CT in the diagnosis and follow-up of coronary aneurysms.

  • Magnetic resonance coronary angiography to evaluate coronary arterial lesions in patients with Kawasaki disease

  • Atsuko Suzuki, Atsushi Takemura, Rikako Inaba, Tomoyoshi Sonobe, Keiji Tsuchiya, Tateo Korenaga
  • Journal:
    Cardiology in the Young / Volume 16 / Issue 6 / December 2006
    Published online by Cambridge University Press:
    20 November 2006, pp. 563-571

  • We evaluated the efficiency of non-invasive magnetic resonance coronary angiography in detecting coronary arterial lesions in 106 patients, aged from 4 months to 37 years, with a median of 13 years, with Kawasaki disease. Non-contrast enhanced, free-breathing magnetic resonance coronary angiographic studies using both the steady-state free precession technique, namely bright blood imaging, and navigator-echo proton density weighted black blood imaging, so-called black blood imaging, were performed in all the patients. Conventional X-ray coronary angiography was performed in 70 patients with coronary arterial lesions.

    We observed 97 aneurysms, 17 dilatations, 17 occlusions, 18 localized stenoses and 10 recanalized vessels, and we clarified their unique pattern of images on magnetic resonance coronary angiography. The differences in size of the aneurysms as seen on X-ray coronary angiography and bright blood imaging was mean 0.0, and the 95% confidence interval was from −1.4 to 1.5 on the Bland-Altman plots. With bright blood imaging, the sensitivity of occlusion and localized stenosis based on X-ray angiography was 94.2% and 97.2%, specificity was 99.5% and 97.2%, and negative-predictive value was 99.5% and 97.2%, respectively. Black blood imaging provided remarkable visualization of the thickened intima of aneurysms, and/or thrombus, in 38 lesions. We conclude that magnetic resonance coronary angiography can visualize all types of lesions due to Kawasaki disease in patients of all ages, and that it is useful to reduce the number of times X-ray angiography needs to be performed in patients with Kawasaki disease.