This study examines the trade-off between agricultural production and groundwater contamination potential for ten potential herbicide cancellations. Theoretical and empirical models are developed for estimating losses in consumer and producer benefits in the agricultural commodity market and changes in groundwater quality. Using com and soybean production in the southeastern Coastal Plain as a study area, the analysis concludes that (1) effects of herbicide cancellations on groundwater quality can be very significant; (2) a cancellation does not guarantee groundwater quality improvement; (3) effects of a multiple cancellation are different from the summation of the effects of independent cancellations; and (4) weed density has a very strong effect on losses to farmers and consumers from cancellations, but output demand and supply elasticities do not.