This articles intervenes in current debates about the configuration of the contemporary literary system and argues that works coming from the intermediate formation of the semi-periphery can most lucidly register how neoliberalism has transformed the social, economic, and affective structures of the historical present. Drawing on postcolonial criticism, world-systems theory, and theories of combined and uneven development, I propose a comparative study of two novels originating from southern India and southern Italy, Vivek Shanbhag’s Ghachar Ghochar (2013) and Nicola Lagioia’s La Ferocia (2014). By analyzing how residual forces—patriarchy, gender violence, and familism—interact with processes of market neoliberalization and environmental destruction, this article further suggests that only the formal study of novels from semi-peripheral areas can problematize current critical paradigms based on binary oppositions (center/periphery, North/South). To do so, I develop a systemic approach that is attentive to how contextual specificities produce formal outcomes that can best diagnose global socioeconomic inequalities.