Neurobehavioral sequelae after concussion may have both somatic and neuropsychiatric components. The impact of injury on neurotransmitter function is poorly defined but clearly could provide a biological explanation for some of the behavioral changes seen after traumatic brain injury (TBI). Chronic traumatic encephalopathy has been associated with both repeat concussion and with genetic predisposition. Before focusing on the neurobehavioral complaints of the patient who has sustained a concussion, a comprehensive history and physical exam is required. The history focuses on the events preceding and succeeding the concussion. The use of neurocognitive testing in athletes before and after injury has contributed to our understanding of postconcussive cognitive performance. Cognitive and physical rest are key components to recovery. Recognizing the possibility of a mild (mTBI) patient developing neurobehavioral sequelae, education is a key component of the discharge process.