In field experiments, wheat row spacing, seeding rate, and herbicide treatment affected cheat seed content of harvested wheat, wheat yield, and net returns. No individual practice or combination of practices consistently increased net returns from cheat-infested wheat. Net returns frequently were increased and never decreased by applying metribuzin at 420 g ha−1 or chlorsulfuron + metsulfuron at 21.9 + 4.4 g ha−1 or by increasing the seeding rate compared to baseline inputs. The data indicate that herbicide rates should not be reduced when row spacing is decreased and/or seeding rates increased.