The practical matter of programming deep brain stimulation (DBS) settings in Parkinson's disease (PD) patients with DBS leads implanted in the globus pallidus internus (GPi), subthalamic nucleus (STN), or pedunculopontine nucleus (PPN) is more complex than thalamic ventral intermedius (Vim) DBS for tremor. Parkinson's disease-associated camptocormia is characterized by marked flexion of the trunk and often responds poorly to pharmacological treatment. This chapter discusses the specific issues pertaining to programming DBS devices in PD patients. In patients with PD and levodopa-induced dyskinesia, spread of stimulation current beyond the Vim to the CM/Pf or Voa/Vop regions of the thalamus may block dyskinesia. In the first two to three months postoperatively, the effects of STN stimulation may seem to wane as the micro-lesion effect associated with surgery diminishes. Understanding and managing the interaction of stimulation and pharmacological therapy is especially important in patients with PD.