The American craft beer industry’s creation narrative is rooted in countercultural food politics. Popular stories describe how plucky brewers pioneered complex and hoppy beers that revolutionized a bland American beer industry dominated by industrial lagers. Hops are now the most celebrated ingredient in the craft beer industry and serve as visual representations of the artisanal and revolutionary values of small brewers that contrasts with the industrial and bland products of the nation’s massive lager brewers. The history of hops and brewing presented here, however, demonstrates the connections between big and small brewers and the environmental impacts of craft brewers’ hoppy beers otherwise obscured by their preferred dichotomous narrative. Craft beer grew in tandem with the modern hop industry and became enmeshed with big business and industrial agricultural practices to access their signature commodity, hops. By integrating environmental and business history, this article explores how brewers, scientists, farmers, and nonhumans influenced each other to create the modern craft brewing industry. This approach demonstrates the often-obscured connections between big and small firms by examining the environments, organisms, and supply chains they depend upon.