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1 results

  • 25 - Panic disorder and agoraphobia

  • from Section 4 - Treatment of anxiety: current status and controversial issues
  • Edited by Helen Blair Simpson, Columbia University, New York, Yuval Neria, Columbia University, New York, Roberto Lewis-Fernández, Columbia University, New York, Franklin Schneier, Columbia University, New York
  • Book:
    Anxiety Disorders
    Published online:
    10 November 2010
    Print publication:
    26 August 2010, pp 284-296

  • Summary

    This chapter reviews the methods for validating animal models of psychiatric disorders and discusses specific models of anxiety in mice. It demonstrates the importance of understanding the validity of a particular animal model, which assists in determining its clinical relevance in the context of careful interpretation. Currently, two main types of genetically modified mice are used in laboratory: knockout mice or knock-in mice and transgenic mice. The chapter reviews how state-of-the-art transgenic technology can be used to make animal models that allow us to consider the contribution of particular genes to anxiety-like behaviors. Several lines of evidence from human studies have implicated the 5-HT1A receptor in affective disorders. The studies of the 5-HT1A receptor provide an illustrative example of the strengths and weaknesses inherent in using the genetic technologies to investigate the pathophysiology of anxiety.