Large carnivores, such as brown bears (Ursus arctos), wolves (Canis lupus), and tigers (Panthera tigris), can play a key ecological role from their apex position in trophic systems. Within the overall context of bottom-up and top-down regulation of ecosystems, predation by large carnivores often induces demographic and behavioral changes in prey species. These vertical interactions between different trophic levels are important regulatory mechanisms in nature. On the other hand, competitive interactions between species, or horizontal interactions within the same trophic level, are also common. Interspecific interactions between large carnivores are widespread in many ecosystems and can play an important role in community structure and stability. Predation is the mechanism driving apex predators’ function in nature, but it is also a source of conflict with different stakeholders, e.g. hunters and livestock owners, when predation affects domestic or semidomestic species (depredation). This situation is challenging when trying to secure long-term carnivore conservation and coexistence with people in the human-dominated landscapes that currently characterize most of our planet.